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| Registros recuperados: 193 | |
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| Rodrick Wallace; Deborah Wallace. |
| We apply Tlusty's information-theoretic index theorem analysis of the genetic code to the glycome, using a cognitive paradigm by which external information sources constrain and tune the glycan code error network, in the context of available metabolic energy. The model suggests spontaneous symmetry breaking of the glycan code as a function of metabolic energy intensity, an effect that may be currently present, or embedded in evolutionary trajectory, recording large-scale ecosystem resilience shifts in energy availability such as the aerobic transition. Once focused on a subset of the glycan error code network however, the glycan production machinery must then be regulated by an elaborate cognitive process to ensure that what is produced matches... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Developmental Biology; Ecology; Molecular Cell Biology; Pharmacology; Evolutionary Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5932/version/2 |
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| Gennadi Glinsky. |
| We report the results of the genome-wide alignment of inter- and intra-chromosomal chromatin interactions within the context of interphase chromatin binding to nuclear lamina and nucleolus. For all human chromosomes, a significant correlation exists between binding of chromosomal loci to nuclear lamina and segregation into spatially-defined distinct compartments of genome-wide chromatin interactions identified by Hi-C method. We report identification of near-centromeric intergenic regions on human chromosomes (chr2; chr10; chr17; chr1), which are highly enriched for interphase chromatin homing sites and function as attractors of long-range physical interactions (Centromeric Regions of Interphase Chromatin Homing, CENTRICH). CENTRICH are engaged in 397-1526... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Developmental Biology; Genetics & Genomics; Molecular Cell Biology; Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6756/version/1 |
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| John Pryor; Laura Reber. |
| Objective: To investigate whether weight stigma influences educators' judgments about psychological symptoms in children.Design: Experimental study manipulating the weight status of children with school problems and examining implicit and explicit anti-fat attitudes as potential moderators of stigmatizing judgments.Subjects: 188 pre-service educators.Measurements: Attributions of laziness as primary dependent variable plus measures of implicit and explicit anti-fat attitudes as potential moderators.Results: Educators were more likely to attribute laziness to overweight children with school problems. Implicit anti-fat attitudes moderated this effect.Conclusion: Spontaneous anti-fat attitudes were importantly related to educators' biases in... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2133/version/1 |
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| Jamie Reilly; David Biun; Wind Cowles; Jonathan Peelle. |
| Where did words come from? The traditional view is that the relation between the sound of a word and its meaning is arbitrary. An alternative hypothesis, known as sound symbolism, holds that form-meaning correspondence is systematic. Numerous examples of sound symbolism exist across natural language phyla. Moreover, cross-linguistic similarities suggest that sound symbolism represents a language universal. For example, many unrelated languages affix an "ee" sound to words in order to emphasize size distinctions or express affection (e.g., look at the teeny weeny baby); other such phonetic universals are evident for object mass, color, brightness, and aggression. We hypothesize that sound symbolism reflects sensitivity to an ecological law... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Ecology; Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2369/version/1 |
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| Robert Hauser; Alberto Palloni. |
| Numerous studies find a positive relationship between cognitive ability, IQ as measured in childhood or youth, and subsequent survival. Explanations range from the idea that low ability is an indicator of adverse systemic events in early life to the idea that high cognitive functioning is required continuously to maintain health and reduce threats to survival. The Wisconsin Longitudinal Study (WLS) has followed a large cohort of Wisconsin high school seniors from ages 18 to 69. As expected, in the WLS survival varies positively with adolescent IQ. However, rank in high school class accounts completely for the relationship between IQ and survival, and it has a much larger effect on survival. These findings suggest that cognitive functioning improves... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4340/version/1 |
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| Rodrick Wallace. |
| Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter disease course. The design of individual or population level interventions will likely require a deeper understanding of protein folding and its regulation than currently provided by contemporary 'physics' or culture-bound medical magic bullet models. Here, a topological rate distortion analysis is applied to the problem of protein folding and regulation that is similar in spirit to Tlusty's (2010a) elegant exploration of the genetic code. The formalism produces... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Developmental Biology; Molecular Cell Biology; Neuroscience; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4847/version/1 |
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| Rodrick Wallace. |
| Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter disease course. The design of individual or population level interventions will likely require a deeper understanding of protein folding and its regulation than currently provided by contemporary 'physics' or culture-bound medical magic bullet models. Here, a topological rate distortion analysis is applied to the problem of protein folding and regulation that is similar in spirit to Tlusty's (2010a) elegant exploration of the genetic code. The formalism produces... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Developmental Biology; Molecular Cell Biology; Neuroscience; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4847/version/2 |
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| Registros recuperados: 193 | |
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